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Sergio Fazio Selected Research

LDL Receptors (LDL Receptor)

1/2021Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.
1/2020Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort.
4/2016Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.
1/2016Local effects of human PCSK9 on the atherosclerotic lesion.
1/2016Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.
7/2014Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.
5/2014The severe hypercholesterolemia phenotype: clinical diagnosis, management, and emerging therapies.
12/2011Novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein.
7/2011Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent.
6/2011Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes.
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Sergio Fazio Research Topics

Disease

79Atherosclerosis
01/2022 - 06/2001
35Cardiovascular Diseases (Cardiovascular Disease)
06/2022 - 07/2003
26Inflammation (Inflammations)
01/2022 - 04/2002
15Insulin Resistance
11/2021 - 06/2001
15Hypercholesterolemia
03/2020 - 10/2002
13Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
01/2022 - 07/2003
12Metabolic Syndrome (Dysmetabolic Syndrome X)
11/2021 - 10/2002
10Dyslipidemias (Dyslipidemia)
11/2021 - 07/2003
9Hypertension (High Blood Pressure)
11/2021 - 07/2003
9Type 2 Diabetes Mellitus (MODY)
03/2021 - 04/2006
9Myocardial Infarction
01/2021 - 01/2006
8Obesity
11/2021 - 12/2003
8Coronary Artery Disease (Coronary Atherosclerosis)
01/2018 - 06/2005
7Coronary Disease (Coronary Heart Disease)
06/2022 - 01/2001
7Thrombosis (Thrombus)
01/2021 - 10/2002
7Chronic Renal Insufficiency
01/2018 - 12/2012
6Hyperlipidemias (Hyperlipidemia)
11/2021 - 10/2002
6Stroke (Strokes)
09/2021 - 07/2003
6Atherosclerotic Plaque (Atheroma)
10/2018 - 01/2005
5Acute Coronary Syndrome
01/2022 - 02/2016
5Hypertriglyceridemia
10/2018 - 09/2013
5Necrosis
08/2015 - 07/2011
4Body Weight (Weight, Body)
01/2020 - 11/2004
4Homozygous Familial Hypercholesterolemia
04/2017 - 05/2014
4Rheumatoid Arthritis
12/2016 - 08/2010
4Neoplasms (Cancer)
07/2015 - 04/2008
4Chronic Kidney Failure (Chronic Renal Failure)
07/2015 - 01/2011
3Abdominal Aortic Aneurysm
01/2014 - 06/2011
2Heart Failure
06/2021 - 04/2006
2Diabetes Mellitus
05/2021 - 01/2021
2Pancreatitis
03/2020 - 11/2017
2Kidney Diseases (Kidney Disease)
01/2018 - 08/2011
2Peripheral Arterial Disease
01/2018 - 07/2011
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
04/2017 - 04/2017
2Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
04/2017 - 04/2017
2Infarction (Infarctions)
04/2017 - 03/2004

Drug/Important Bio-Agent (IBA)

36CholesterolIBA
10/2020 - 12/2002
33LipidsIBA
06/2022 - 06/2001
32Apolipoproteins E (ApoE)IBA
01/2022 - 06/2001
25ApolipoproteinsIBA
10/2020 - 06/2001
23oxidized low density lipoproteinIBA
06/2022 - 07/2003
21Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
06/2022 - 01/2001
21LDL Receptors (LDL Receptor)IBA
01/2021 - 04/2002
20Triglycerides (Triacylglycerol)IBA
09/2021 - 03/2004
18Lipoproteins (Lipoprotein)IBA
07/2019 - 12/2003
17LDL CholesterolIBA
06/2022 - 07/2003
17Proteins (Proteins, Gene)FDA Link
10/2020 - 12/2003
15Proprotein Convertase 9IBA
06/2022 - 12/2011
14LDL Lipoproteins (beta Lipoproteins)IBA
01/2020 - 11/2002
13HDL CholesterolIBA
09/2021 - 09/2007
12HDL LipoproteinsIBA
09/2021 - 12/2003
8C-Reactive ProteinIBA
09/2021 - 07/2003
7Biomarkers (Surrogate Marker)IBA
11/2021 - 11/2007
7Glucose (Dextrose)FDA LinkGeneric
06/2021 - 10/2002
7Fatty Acid-Binding ProteinsIBA
06/2011 - 06/2001
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2022 - 03/2007
6Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA
01/2022 - 03/2007
6Apolipoproteins B (ApoB)IBA
01/2020 - 10/2007
6Niacin (Nicotinic Acid)FDA LinkGeneric
02/2016 - 02/2008
6Angiotensin IIIBA
01/2014 - 11/2004
6Interleukin-6 (Interleukin 6)IBA
12/2012 - 04/2006
6Insulin (Novolin)FDA Link
12/2011 - 10/2002
5Adenosine Triphosphate (ATP)IBA
04/2017 - 12/2002
5AngiotensinsIBA
01/2014 - 08/2007
5Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
01/2008 - 04/2002
4Lipoprotein(a)IBA
10/2019 - 01/2018
4Fibric Acids (Fibrates)IBA
11/2017 - 03/2004
4Fenofibrate (CiL)FDA LinkGeneric
04/2017 - 02/2008
4Pharmaceutical PreparationsIBA
04/2017 - 03/2004
4Scavenger Receptors (Scavenger Receptor)IBA
08/2015 - 06/2005
4CytokinesIBA
02/2015 - 11/2010
3PCSK9 InhibitorsIBA
06/2022 - 01/2018
3Simvastatin (Zocor)FDA LinkGeneric
01/2022 - 04/2008
3AntibodiesIBA
01/2022 - 11/2002
3CollagenIBA
01/2017 - 08/2007
3Type 1 Angiotensin ReceptorIBA
12/2011 - 12/2002
3Apolipoprotein A-I (Apolipoprotein A1)IBA
11/2010 - 10/2003
3ElastinIBA
08/2007 - 11/2004
3Indomethacin (Indometacin)FDA LinkGeneric
09/2005 - 04/2002
3rofecoxib (Vioxx)FDA Link
09/2005 - 04/2002
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
04/2004 - 10/2002
2Atorvastatin (Lipitor)FDA Link
01/2022 - 04/2017
2Rosuvastatin Calcium (Crestor)FDA Link
01/2022 - 04/2017
2alirocumabIBA
01/2022 - 06/2016
2Metformin (Glucophage)FDA LinkGeneric
03/2021 - 11/2017
2Oxidoreductases (Dehydrogenase)IBA
10/2020 - 09/2010
2Amyloid (Amyloid Fibrils)IBA
10/2020 - 11/2010
2CreatinineIBA
01/2019 - 12/2011
2evolocumabIBA
01/2019 - 06/2016
2CC ChemokinesIBA
01/2019 - 10/2018
2Lipoprotein Lipase (Diacylglycerol Lipase)IBA
11/2017 - 10/2007
21-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)IBA
04/2017 - 04/2017
2VLDL CholesterolIBA
04/2017 - 04/2017
2BezafibrateIBA
04/2017 - 03/2004
2Simvastatin Drug Combination Ezetimibe (Vytorin)FDA Link
04/2017 - 02/2010

Therapy/Procedure

25Therapeutics
06/2022 - 01/2001
5Cell Transplantation
01/2011 - 10/2002
3Drug Therapy (Chemotherapy)
03/2020 - 01/2016
3Blood Component Removal (Apheresis)
01/2019 - 12/2013
3Bone Marrow Transplantation (Transplantation, Bone Marrow)
08/2015 - 06/2001